5. Alex Pereira vs. Sean Strickland – UFC 276

Alex Pereira recently defeated Israel Adesanya and became the middleweight champion in 2022. But his best knockout came when he landed a brutal left hook on Sean Strickland’s face, he didn’t even need to follow the shot up as the fight was over already by knockout.

4. Molly McCann vs. Luana Carolina – UFC Fight Night

Molly McCann landed a ridiculous spinning elbow on Luana Carolina’s jaw which ended the things for her as Carolina went to sleep. The fight ended there as Carolina couldn’t get up after that huge blow on the face. It was one of the best knockouts of 2022.

3. Weili Zhang vs. Joanna Jedrzejczyk – UFC 275

Weili Zhang and Joanna Jedrzejczyk faced off against each other in UFC 275. Zhang landed a deadly side kick to Joanna’s body after some back-and-forth action. The kick followed by a brilliant spinning backfist. 

2. Leon Edwards vs. Kamaru Usman – UFC 278

Leon Edwards redefined the meaning of an all-or-nothing knockout as he landed a perfect head kick to Kamaru Usman in the main event of UFC 278 in 2022. Edwards lost to Usman in 2015 and revenged the loss in 2022 in a strylish way.

1. Michael Chandler vs. Tony Ferguson – UFC 274

Michael Chandler delivered one of the greatest knockouts in UFC history against Tony Ferguson. Chandler’s explosive power was on full display when he faced Ferguson at UFC 274 in May, 2022. He hammered him with probably the most brutal front kick in MMA history.