Jose Mourinho and Lionel Messi first met in a Champions League match between Chelsea and Barcelona in 2006. In the match, Messi was blamed for Asier del Horno’s dismissal just eight minutes before halftime. A furious Mourinho didn't hold back and questioned Messi's ethics and called him out for acting.
The Argentine struggled at the Rosaleda Stadium, where Malaga players meticulously man-marked him in torrential rain. He encountered Duda several times before finally snapping and spitting on him towards the end. It all happened in a La Liga game in 2008.
In the 2018 Copa America, Messi got into an argument with Gary Medal. It happened after the ball was kicked behind for a goal. Things got heated between the two before the referee dismissed them. Messi later stunned reporters by openly accusing CONMEBOL of corruption.